Home / Focus & sleep / DSIP
DsHuman trials

DSIP protocol

DSIP (delta sleep-inducing peptide) is a 9-amino-acid peptide first studied for sleep in the 1980s. Small old trials gave mixed results. In Russia a nasal form is registered for stress states and alcohol withdrawal, not for sleep.

Registered in Russia as Deltaran (nasal), for stress states and alcohol withdrawalNot approved for sleep or insomnia in any country I found
ProtocolMixingResultsSide effectsHow it worksSources

The protocol at a glance

The Russian nasal label gives 1 to 3 ampoules (0.3 mg each) a day for 5 to 10 days. Sleep trials used a weight-based dose by vein.

SourceAmount and length
Deltaran label (nasal)0.3 mg per ampoule, 1 to 3 ampoules a day, 5 to 10 days
Sleep trials, 1981 and 199225 nmol per kg of body weight, by vein
1987 insomnia trial6 injections over 7 nights (dose not in the abstract)

Deltaran: RLS entry (label revised 2019, State Research Institute of Highly Pure Biopreparations, FMBA). By my own arithmetic, 25 nmol per kg is about 21 mcg per kg, roughly 1.5 mg for a 70 kg adult; this uses a molecular weight of about 849. No label covers sleep use.

Community reports

Community notes report 200 to 600 mcg before bed, 5 days on and 2 off, for 4 to 8 weeks. These are user reports, not trial data.

What people say they do, collected from community discussions. Not tested in a trial; shown so you can compare it with the evidence above.

Mixing

No mixing table here: this one is used as a capsule, nasal spray or skin product, or has no human amount to calculate from. The general mixing calculator works for any vial.

What the trials found

Three small trials in chronic insomnia, with mixed results:

6Patients in the first study (1981): longer, better sleep after one injection
14Patients in a placebo-controlled 1987 trial: better night sleep and daytime alertness over 7 nights
16Patients in a double-blind 1992 trial: weak effects; authors judged it unlikely to be of major benefit

Schneider-Helmert D, Schoenenberger GA, Experientia 1981 (PMID 7028502); Schneider-Helmert D, Eur Neurol 1987 (PMID 3622582); Bes F et al., Neuropsychobiology 1992 (PMID 1299794).

Side effects

  • The 1981 study (6 patients) reported no daytime sedation or other side effects.
  • The Deltaran label lists allergic reactions and nasal irritation. It is not for use in pregnancy, breastfeeding or under age 18.

How it works

Not settled

A 1986 review says how DSIP works is still unknown, with a possible role in adrenergic signaling.

Sources

  • RLS (rlsnet.ru) Deltaran lyophilisate for intranasal solution 0.3 mg, reg. no. ЛП-№(016126)-(РГ-RU)
  • Schneider-Helmert D, Schoenenberger GA. Experientia 1981, PMID 7028502
  • Schneider-Helmert D. Eur Neurol 1987, PMID 3622582
  • Bes F et al. Neuropsychobiology 1992, PMID 1299794
  • DSIP: an update. Peptides 1986, PMID 3550726